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The impact of hypoxia in hepatocellular carcinoma metastasis
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《医学前沿(英文)》 2014年 第8卷 第1期 页码 33-41 doi: 10.1007/s11684-013-0301-3
Hypoxia is a common phenomenon in hepatocellular carcinoma (HCC). Hypoxia stabilizes transcription factor, hypoxia-inducible factor (HIF), to activate gene transcription. Expression of HIF is closely associated with metastasis and poor prognosis in HCC. HIF mediates expression of genes that are involved in every step of HCC metastasis including epithelial-mesenchymal transition, invasion of the extracellular matrix, intravasation, extravasation, and secondar y growth of the metastases. Because HIF is the central regulator of HCC metastasis, HIF inhibitors are attractive tools when used alone or as combined treatment to curb HCC metastasis. This review will summarize the current findings on the impact of hypoxia/HIF in HCC, with a particular focus on cancer metastasis.
关键词: hypoxia hepatocellular carcinoma (HCC) metastasis hypoxia-inducible factor (HIF)
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《医学前沿(英文)》 2018年 第12卷 第1期 页码 3-22 doi: 10.1007/s11684-017-0605-9
For the past several decades, the infectious disease profile in China has been shifting with rapid developments in social and economic aspects, environment, quality of food, water, housing, and public health infrastructure. Notably, 5 notifiable infectious diseases have been almost eradicated, and the incidence of 18 additional notifiable infectious diseases has been significantly reduced. Unexpectedly, the incidence of over 10 notifiable infectious diseases, including HIV, brucellosis, syphilis, and dengue fever, has been increasing. Nevertheless, frequent infectious disease outbreaks/events have been reported almost every year, and imported infectious diseases have increased since 2015. New pathogens and over 100 new genotypes or serotypes of known pathogens have been identified. Some infectious diseases seem to be exacerbated by various factors, including rapid urbanization, large numbers of migrant workers, changes in climate, ecology, and policies, such as returning farmland to forests. This review summarizes the current experiences and lessons from China in managing emerging and re-emerging infectious diseases, especially the effects of ecology, climate, and behavior, which should have merits in helping other countries to control and prevent infectious diseases.
关键词: infectious disease profile emerging infectious diseases influence factor
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《医学前沿(英文)》 2012年 第6卷 第1期 页码 94-99 doi: 10.1007/s11684-012-0181-y
Systematic reviews and meta-analyses are playing an increasingly important role in clinical research and practice. This study aimed to measure the scientific production of systematic review and meta-analysis from the three major regions of China: the Mainland (ML), Hong Kong (HK), and Taiwan (TW). English articles on systematic review and meta-analysis from ML, HK, and TW from 2001 to 2010 were retrieved from the PubMed database. The total number of articles, impact factors (IF), and articles published in high-impact journals were conducted for quantity and quality comparisons among the three regions. There were 1 587 published articles from ML (1 292), HK (203), and TW (92) during the past ten years. The annual total numbers of articles in the three regions increased significantly from 2001 to 2010 (from 13 to 677). The number of articles from ML has exceeded that from TW since 2001, and surpassed that from HK in 2003. The accumulated IF of articles from ML (3 488.24) was higher than those from HK (493.16) and TW (216.39). HK had the highest average IF of 3.31, followed by ML of 2.90 and TW of 2.85. Researchers from HK published a larger proportion of papers in high-impact journals than those from ML and TW. The Cochrane Database of Systematic Reviews was the most popular journal in China. Chinese authors have been very active to enhance the systematic review and meta-analysis research over the past ten years, especially in ML. The gap between ML and the other two regions has been narrowed. But there is still considerable room for Chinese authors to improve their studies on systematic review and meta-analysis.
关键词: systematic review meta-analysis China Chinese impact factor
Game theoretic analysis of environmental impact assessment system in China
CHENG Hongguang, PU Xiao, GONG Li, QI Ye
《环境科学与工程前沿(英文)》 2007年 第1卷 第4期 页码 448-453 doi: 10.1007/s11783-007-0071-8
《医学前沿(英文)》 2023年 第17卷 第3期 页码 527-533 doi: 10.1007/s11684-022-0967-5
关键词: orthotopic heart transplant tricuspid regurgitation clinical impact biatrial heart transplantation
Dynamical analysis of droplet impact spreading on solid substrate
Zhaomiao LIU, Huamin LIU, Xin LIU,
《机械工程前沿(英文)》 2010年 第5卷 第3期 页码 308-315 doi: 10.1007/s11465-010-0020-2
Role of the forkhead transcription factor FOXO-FOXM1 axis in cancer and drug resistance
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《医学前沿(英文)》 2012年 第6卷 第4期 页码 376-380 doi: 10.1007/s11684-012-0228-0
The forkhead transcription factors FOXO and FOXM1 have pivotal roles in tumorigenesis and in mediating chemotherapy sensitivity and resistance. Recent research shows that the forkhead transcription factor FOXM1 is a direct transcriptional target repressed by the forkhead protein FOXO3a, a vital downstream effector of the PI3K-AKT-FOXO signaling pathway. Intriguingly, FOXM1 and FOXO3a also compete for binding to the same gene targets, which have a role in chemotherapeutic drug action and sensitivity. An understanding of the role and regulation of the FOXO-FOXM1 axis will impact directly on our knowledge of chemotherapeutic drug action and resistance in patients, and provide new insights into the design of novel therapeutic strategy and reliable biomarkers for prediction of drug sensitivity.
关键词: FOXO3a FOXM1 transcription factor cancer drug resistance tumorigenesis
LSSVM-based approach for refining soil failure criteria and calculating safety factor of slopes
Shiguo XIAO; Shaohong LI
《结构与土木工程前沿(英文)》 2022年 第16卷 第7期 页码 871-881 doi: 10.1007/s11709-022-0863-8
关键词: slope stability safety factor failure criterion least square support vector machine
lncR-GAS5 upregulates the splicing factor to impair endothelial autophagy, leading to atherogenesis
《医学前沿(英文)》 2023年 第17卷 第2期 页码 317-329 doi: 10.1007/s11684-022-0931-4
关键词: lncR-GAS5 miR-193-5p splicing factor SRSF10 autophagy atherogenesis
The calculation of equivalence factor for ecological footprints in China: a methodological note
Moucheng LIU,Wenhua LI,Dan ZAHNG,Ning SU
《环境科学与工程前沿(英文)》 2015年 第9卷 第6期 页码 1015-1024 doi: 10.1007/s11783-014-0670-0
关键词: ecological footprint equivalence factor net primary production biological capacity land types
Comparison of droplet distributions from fluidic and impact sprinklers
Xingye ZHU,Shouqi YUAN,Junping LIU,Xingfa LIU
《农业科学与工程前沿(英文)》 2015年 第2卷 第1期 页码 53-59 doi: 10.15302/J-FASE-2015049
关键词: outside signal sprinkler fluidic sprinkler impact sprinkler sprinkler irrigation droplet size droplet velocity
Mechanical properties and impact resistance of concrete composites with hybrid steel fibers
Fatih ÖZALP; Halit Dilşad YILMAZ; Burcu AKCAY
《结构与土木工程前沿(英文)》 2022年 第16卷 第5期 页码 615-623 doi: 10.1007/s11709-022-0828-y
关键词: projectile impact depth of penetration fracture energy crater diameter UHPFRC
Hazard potential of zones of weakness in gravity dams under impact loading conditions
Herbert LINSBAUER
《结构与土木工程前沿(英文)》 2011年 第5卷 第1期 页码 90-97 doi: 10.1007/s11709-010-0008-3
关键词: dam-reservoir earthquake impact cracking fracture mechanics
Ying YAN, Pengfei LI, Shunying JI
《结构与土木工程前沿(英文)》 2013年 第7卷 第1期 页码 50-54 doi: 10.1007/s11709-013-0186-x
关键词: granular matter impact peak buffer capacity discrete element method critical thickness
《结构与土木工程前沿(英文)》 2021年 第15卷 第4期 页码 877-894 doi: 10.1007/s11709-021-0756-2
关键词: bridges multi-lane factor traffic load lane load disparity multi-truck presence weigh-in-motion data
标题 作者 时间 类型 操作
Landscape of emerging and re-emerging infectious diseases in China: impact of ecology, climate, and behavior
null
期刊论文
Scientific publications on systematic review and meta-analysis from Chinese authors: a 10-year survey of the English literature
null
期刊论文
Game theoretic analysis of environmental impact assessment system in China
CHENG Hongguang, PU Xiao, GONG Li, QI Ye
期刊论文
The clinical impact of tricuspid regurgitation in patients with a biatrial orthotopic heart transplant
期刊论文
Dynamical analysis of droplet impact spreading on solid substrate
Zhaomiao LIU, Huamin LIU, Xin LIU,
期刊论文
LSSVM-based approach for refining soil failure criteria and calculating safety factor of slopes
Shiguo XIAO; Shaohong LI
期刊论文
lncR-GAS5 upregulates the splicing factor to impair endothelial autophagy, leading to atherogenesis
期刊论文
The calculation of equivalence factor for ecological footprints in China: a methodological note
Moucheng LIU,Wenhua LI,Dan ZAHNG,Ning SU
期刊论文
Comparison of droplet distributions from fluidic and impact sprinklers
Xingye ZHU,Shouqi YUAN,Junping LIU,Xingfa LIU
期刊论文
Mechanical properties and impact resistance of concrete composites with hybrid steel fibers
Fatih ÖZALP; Halit Dilşad YILMAZ; Burcu AKCAY
期刊论文
Hazard potential of zones of weakness in gravity dams under impact loading conditions
Herbert LINSBAUER
期刊论文
Buffer capacity of granular matter to impact of spherical projectile based on discrete element method
Ying YAN, Pengfei LI, Shunying JI
期刊论文